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What is Cicatricial Pemphigoid and definition
Cicatricial pemphigoid occurs when the body’s IMMUNE SYSTEM produces antibodies that attack the cells that form the mucus membranes. Trauma appears to activate the eruptions of blisters and may be as inconsequential as rubbing the eye or the irritation such as occurs with exposure to environmental particulates such as pollen and dust. Some people first experience outbreaks of cicatricial pemphigoid following eye operations such as CATARACT EXTRACTION AND LENS REPLACEMENT or BLEPHAROPLASTY.
The diagnostic path includes laboratory tests to assess the levels of antibodies in the blood, particularly IMMUNOGLOBULIN G (IGG) and IMMUNOGLOBIN A (IGA), the antibodies most closely associated with cicatricial pemphigoid. Treatment focuses on reducing BLISTER formation and minimizing scarring, typically by taking oral CORTICOSTEROID MEDICATIONS or IMMUNOSUPPRESSIVE MEDICATIONS. As with other AUTOIMMUNE DISORDERS, cicatricial pemphigoid tends to be chronic and recurrent. The persistent irritation can result in damage to the cornea that causes VISUAL IMPAIRMENT and, when severe, results in blindness.