Definition of Hemolysis

The destruction and disassembly of erythrocytes (red blood cells). Erythrocytes live in the blood for about 120 days after their release from the bone marrow. At the end of this time they either die or the spleen culls them from circulation.

The spleen partially dismantles the erythrocytes, reducing toxic heme into bilirubin that the body excretes with the bile. The liver then recycles these components for numerous other uses in the body. Accelerated hemolysis, which results in anemia, can occur with, or characterizes, various disorders.

CONDITIONS IN WHICH HEMOLYSIS MAY OCCUR
Adverse drug reactionsBlood enzyme disorders
Blood transfusion reactionErythrocyte metabolic disorders
hemoglobin disordersImmune System dysfunction
SepticemiaSickle Cell Disease
Systemic lupus erythematosus (SLE)Thalassemia

See also APOPTOSISCELL STRUCTURE AND FUNCTIONPHAGOCYTOSISSPLENOMEGALY.

How did you like this article?

Page last reviewed:

About Us