Immune Response and Immune System

Immune Response Definition The multiple mechanisms and processes through which the body identifies and reacts to antigens. The immune response is the body’s primary means of protecting itself from infection. There are three independent yet complementary immune response pathways: Antibodymediated immunity (also called humoral immunity), cell-mediated immunity, and the complement cascade. As well, the immune response stimulates activity from […]

Read More

Immunity and Human Immune System – Definition

Immunity Definition Immunity Definition – an established base of protection against infection. Immunity may be innate, passive, or acquired. Innate immunity, also called natural immunity, is present at birth and provides effective protection against a broad base of common pathogens. Innate immunity is limited in scope. Passive immunity is antibody-specific but present without activation of the immune response. A newborn has […]

Read More

Immunoablation and Bone Marrow Transplantation

Immunoablation Definition The therapeutic destruction of the body’s immune response, typically to prepare for bone marrow transplantation or stem cell transplantation. Immunoablation is usually a step in the treatment process for certain cancers and autoimmune disorders, such as severe multiple sclerosis. High-dose chemotherapy and radiation therapy are the most common methods of immunoablation. The goal is to remove all T-cell lymphocytes from the […]

Read More

Immunocompromised – Definition

Immunocompromised Definition Any circumstance in which the immune system lacks the capacity, as the consequence of an acquired health condition or a medication side effect, to protect the body from infection. diabetes is the most common reason people become immunocompromised. People who are taking immunosuppressive therapy after organ transplantation or to treat severe autoimmune disorders are also immunocompromised. People who are immunocompromised often struggle […]

Read More

Immunosenescence – Definition

Definition of Immunosenescence A decline in immune function and immune response that occurs with aging. Researchers believe immunosenescence accounts for the increase in cancer and infections such as influenza and pneumonia in people of old age. The decline occurs in both cell-mediated immunity (sometimes called cytotoxic immunity), in which T-cell lymphocytes attack and kill foreign antigens, and humoral immunity, in which […]

Read More

Immunosuppressive Medications / Drugs

Immunosuppressive Medications Definition Drugs that limit or suppress some aspect of the immune response. Immunosuppressive medications such as cyclosporine work by many different mechanisms with the goal being to block the body’s rejection of a transplanted organ or bone marrow and to prevent graft vs. host disease. Common immunosuppressive medications include Corticosteroid medications, which inhibit the production […]

Read More

Immunosuppressive Therapy

Immunosuppressive Therapy Definition Treatments that limit or suppress the immune response. Such treatment may incorporate immunosuppressive medications such as corticosteroid medications, diseasemodifying anti-rheumatic drugs (dmards), chemotherapy, radiation therapy, and monoclonal antibodies (mabs). Doctors may prescribe short-term immunosuppressive therapy (two to six weeks) to treat moderate to severe type I hypersensitivity reaction or to reduce inflammation due to injury. Long-term immunosuppressive therapy is generally a treatment […]

Read More

Immunotherapy – Cancer and Allergy Treatment

Immunotherapy Definition The therapeutic use of biologic agents to manipulate the mechanisms of the immune system. Immunotherapy, also called biologic response modification, is an effective method for reducing inflammation and other aspects of the immune response to treat inflammatory autoimmune disorders such as rheumatoid arthritis. Immunotherapy is also a treatment option formany forms of cancer. The common types of immunotherapy are […]

Read More

Immunization – Definition

Immunization Definition The mechanism through which the body protects itself from subsequent infection with the same pathogen. Immunization may occur as a natural consequence of infection or through vaccination (also called inoculation). The immune system creates unique antibodies, specialized proteins that attach to B-cell lymphocytes that circulate in the blood and the lymph, in response to antigens present on the cell surfaces of […]

Read More

Innate Immunity

Innate Immunity Definition The level of immune protection with which an individual is born. Researchers believe innate immunity, also called natural immunity, is the result of genetically encoded pathogen recognition-that is, gene-regulated ability to identify and mount an immune response to neutralize certain bacteria , viruses, and other substances capable of causing infection or otherwise doing harm to the […]

Read More