Disease-modifying antirheumatic drugs (DMARDs)

What are Disease-modifying antirheumatic drugs (DMARDs) Disease-modifying antirheumatic drugs are medications that alter the IMMUNE RESPONSE slow or stop the progression of certain degenerative, AUTOIMMUNE DISORDERS. The most common use of DMARDs is to treat RHEUMATOID ARTHRITIS. DMARDs provide relief from symptoms such as INFLAMMATION and pain, and in many people also reduce the JOINT deformities associated with rheumatoid […]

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Healing Process – what is and definition

Healing Process Definition The processes and mechanisms by which the body repairs itself. Healing represents complex and cascading interactions among various of the body’s systems and mechanisms. Among the first to respond are the COAGULATION cascade, to stop bleeding, and the IMMUNE RESPONSE, which mobilizes T-cell lymphocytes, macrophages, antibodies, the COMPLEMENT CASCADE, and the release of CYTOKINES and PROSTAGLANDINS. Fibroblasts (cells […]

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Immune Response and Immune System

Immune Response Definition The multiple mechanisms and processes through which the body identifies and reacts to antigens. The immune response is the body’s primary means of protecting itself from INFECTION. There are three independent yet complementary immune response pathways: ANTIBODYMEDIATED IMMUNITY(also called humoral immunity), CELL-MEDIATED IMMUNITY, and the COMPLEMENT CASCADE. As well, the immune response stimulates activity from the […]

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Immunity and Human Immune System – Definition

Immunity Definition Immunity Definition – an established base of protection against INFECTION. Immunity may be innate, passive, or acquired. INNATE IMMUNITY, also called natural immunity, is present at birth and provides effective protection against a broad base of common pathogens. Innate immunity is limited in scope. PASSIVE IMMUNITY is ANTIBODY-specific but present without activation of the IMMUNE RESPONSE. A newborn has […]

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Immunoablation and Bone Marrow Transplantation

Immunoablation Definition The therapeutic destruction of the body’s IMMUNE RESPONSE, typically to prepare for BONE MARROW TRANSPLANTATION or STEM CELL transplantation. Immunoablation is usually a step in the treatment process for certain cancers and AUTOIMMUNE DISORDERS, such as severe MULTIPLE SCLEROSIS. High-DOSE CHEMOTHERAPY and RADIATION THERAPY are the most common methods of immunoablation. The goal is to remove all T-cell lymphocytes from the […]

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Immunocompromised

Immunocompromised Definition Any circumstance in which the IMMUNE SYSTEM lacks the capacity, as the consequence of an acquired health condition or a medication side effect, to protect the body from INFECTION. DIABETES is the most common reason people become immunocompromised. People who are taking IMMUNOSUPPRESSIVE THERAPY after ORGAN TRANSPLANTATION or to treat severe AUTOIMMUNE DISORDERS are also immunocompromised. People who are immunocompromised often struggle […]

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Immunosenescence – definition

What is Immunosenescence and Definition A decline in immune function and IMMUNE RESPONSE that occurs with aging. Researchers believe immunosenescence accounts for the increase in cancer and infections such as INFLUENZA and PNEUMONIA in people of old age. The decline occurs in both CELL-MEDIATED IMMUNITY (sometimes called cytotoxic immunity), in which T-cell lymphocytes attack and kill foreign antigens, and humoral immunity, […]

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Immunosuppressive medications / drugs

Immunosuppressive Medications Definition Drugs that limit or suppress some aspect of the IMMUNE RESPONSE. Immunosuppressive medications such as cyclosporine work by many different mechanisms with the goal being to block the body’s rejection of a transplanted organ or bone marrow and to prevent GRAFT VS. HOST DISEASE. Common immunosuppressive medications include CORTICOSTEROID MEDICATIONS, which inhibit the production […]

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Immunosuppressive therapy

Immunosuppressive Therapy Definition Treatments that limit or suppress the IMMUNE RESPONSE. Such treatment may incorporate IMMUNOSUPPRESSIVE MEDICATIONS such as CORTICOSTEROID MEDICATIONS, DISEASEMODIFYING ANTI-RHEUMATIC DRUGS (DMARDS), CHEMOTHERAPY, RADIATION THERAPY, and MONOCLONAL ANTIBODIES (MABS). Doctors may prescribe short-term immunosuppressive therapy (two to six weeks) to treat moderate to severe type I HYPERSENSITIVITY REACTION or to reduce INFLAMMATION due to injury. Long-term immunosuppressive therapy is generally a treatment […]

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Immunotherapy – Cancer and Allergy Treatment

Immunotherapy Definition The therapeutic use of biologic agents to manipulate the mechanisms of the IMMUNE SYSTEM. Immunotherapy, also called biologic response modification, is an effective method for reducing INFLAMMATION and other aspects of the IMMUNE RESPONSE to treat inflammatory AUTOIMMUNE DISORDERS such as RHEUMATOID ARTHRITIS. Immunotherapy is also a treatment option formany forms of cancer. The common types of immunotherapy are […]

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