Discoid Lupus Erythematosus (DLE)

Definition of Discoid Lupus Erythematosus (DLE) Discoid Lupus Erythematosus (DLE) is a chronic autoimmune disorder, also called cutaneous lupus erythematosus, in which roughly circular, reddened patches (erythematous lesions) form on the SKIN. The lesions are most common on the face, back of the neck, scalp, inner lips and mouth, and outer portions of the auditory (EAR) canals. […]

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Autoimmune disorders

What are Autoimmune disorders and Definition Health conditions in which the body’s IMMUNE RESPONSE loses the ability to identify certain self cells and attacks them. Autoimmune disorders may produce symptoms that are localized (affect a clearly defined part of the body), systemic (affect a body system), or generalized (affect the body as a whole or across several […]

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Common variable immunodeficiency (CVID)

What is Common variable immunodeficiency Common variable immunodeficiency (CVID) – an immune disorder in which the IMMUNE SYSTEMlacks the ability to produce adequate antibodies to protect the body from INFECTION. Though there are normal numbers of B-lymphocytes in the BLOOD circulation, these ANTIBODY-producing cells are lacking IMMUNOGLOBULIN G (IgG), a protein essential for ANTIGEN recognition and antibody production. IgG is the foundation for most antibodies […]

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Graft vs. Host Disease – symptoms and treatment

Graft vs. Host Disease Definition Graft vs. Host Disease – a life-threatening condition in which the immune cells (leukocytes and lymphocytes) contained in allogeneic transplanted BONE MARROW (the graft, from a donor source) produce antibodies that attack other organs in the organ transplant recipient’s body (the host). BONE MARROW TRANSPLANTATION(or BLOOD STEM CELL transplantation) is the primary […]

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Granuloma – what is and definition

What is Granuloma and Definition An accumulation of granulocytes (also called polymorphonuclear leukocytes [PMNs]) and other cells that contain and enclose an area of INFLAMMATION at the site of cell injury, usually due to INFECTION. The effect is to “wall off” the area so the infection cannot spread. The resulting construction is fibrous (SCAR-like). Over time the PATHOGEN causing the […]

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Immune Disorders – symptoms and treatment

Immune Disorders Definition Chronic conditions of the IMMUNE SYSTEM that affect the IMMUNE RESPONSE and the body’s ability to protect and defend itself against INFECTION. Immune disorders generally result from a deficiency or absence of some component or structure of immune function. Such a deficiency may be primary, which is congenital (present at birth), genetic (inherited), or acquired (develops during life). […]

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Living with immune disorders

Living with Immune Disorders – Information Living with an immune disorder requires special attention to circumstances that increase the risk for INFECTION. IMMUNE DISORDERS increase susceptibility to infection either as a direct result of the disease process or, in AUTOIMMUNE DISORDERS, as a consequence of the medications necessary to keep symptoms in check. The most important factor for […]

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Multiple chemical sensitivity syndrome

Multiple Chemical Sensitivity Syndrome Definition A constellation of symptoms that result from exposure to common chemicals at levels that do not normally cause response or reaction. Multiple chemical sensitivity syndrome is difficult to diagnose and treat. Symptoms are often broad ranging. There remains disagreement among medical experts (doctors and researchers) about the diagnostic criteria and […]

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Partial combined immunodeficiency (PCID)

Partial Combined immunodeficiency Disorder Definition An immune disorder in which the IMMUNE SYSTEM is missing key components. Most often people who have PCID lack certain leukocytes (white BLOOD cells), which impairs their ability to form antibodies (develop IMMUNITY) and fight INFECTION. The abnormality might be with cell differentiation, maturity, or function. Sometimes PCID involves deficits of complement […]

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Rheumatoid Arthritis – symptoms, causes and treatment

Rheumatoid Arthritis Definition Rheumatoid Arthritis – a chronic, autoimmune disorder in which nodules and INFLAMMATION develop within the synovial capsules of the joints, causing erosion of the BONE and connective tissues, eventually deforming the JOINT. Synovial membranes encapsulate the joints and secrete synovial fluid, which lubricates the structures of the joint so they move smoothly […]

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