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The therapeutic destruction of the body’s immune response, typically to prepare for bone marrow transplantation or stem cell transplantation. Immunoablation is usually a step in the treatment process for certain cancers and autoimmune disorders, such as severe multiple sclerosis.
High-dose chemotherapy and radiation therapy are the most common methods of immunoablation. The goal is to remove all T-cell lymphocytes from the blood, which destroys the body’s cell-mediated immunity. Until the person’s immune system restores immune functions, the person is extremely vulnerable to any infection. A person who has undergone immunoablation stays in a hospital in strict isolation until immune function returns after bone marrow or stem cell transplantation.
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