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The therapeutic destruction of the body’s IMMUNE RESPONSE, typically to prepare for BONE MARROW TRANSPLANTATION or STEM CELL transplantation. Immunoablation is usually a step in the treatment process for certain cancers and AUTOIMMUNE DISORDERS, such as severe MULTIPLE SCLEROSIS.
High-DOSE CHEMOTHERAPY and RADIATION THERAPY are the most common methods of immunoablation. The goal is to remove all T-cell lymphocytes from the BLOOD, which destroys the body’s CELL-MEDIATED IMMUNITY. Until the person’s IMMUNE SYSTEM restores immune functions, the person is extremely vulnerable to any INFECTION. A person who has undergone immunoablation stays in a hospital in strict isolation until immune function returns after bone marrow or stem cell transplantation.