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Any circumstance in which the immune system lacks the capacity, as the consequence of an acquired health condition or a medication side effect, to protect the body from infection. diabetes is the most common reason people become immunocompromised. People who are taking immunosuppressive therapy after organ transplantation or to treat severe autoimmune disorders are also immunocompromised.
People who are immunocompromised often struggle to fight off common infections such as colds and urinary tract infection (uti) and are vulnerable to opportunistic infection (an infection that a healthy immune system would easily rebuff).