What is Infertility and Definition

Infertility – the inability to conceive or maintain a PREGNANCY. Infertility may be transitory (relate to a specific set of circumstances), treatable, or permanent. Infertility affects about 10 percent of Americans who attempt pregnancy.

There are numerous possible causes of infertility that can affect any of the various stages in the process of CONCEPTION. Causes may affect the woman, the man, or the couple in equal distribution. One of the most significant is the woman’s age. An increasing number of women in the United States delay starting their families until completing their education and establishing their careers, the average age of first pregnancy is age 30. Though a woman can remain fertile into her late 40s, the likelihood of conception appreciably diminishes each year after age 35.

Infertility is highly emotional for most people. Infertility often comes as a shock, particularly for younger people who had no reason to suspect they were not fertile. Some people feel guilt or regret about choices made earlier in life in regard to CONTRACEPTION and FAMILY PLANNING. Diagnostic procedures and treatment approaches can be invasive and expensive and are without assurances. Though ASSISTED REPRODUCTIVE TECHNOLOGY (ART) is highly advanced and makes pregnancy possible for thousands of couples every year, it nonetheless is unable to help two thirds of couples who cannot conceive.

Female factor infertility

In female factor infertility the reason for infertility rests with the woman. A third of infertility circumstances arise from female factors. Ovulatory dysfunction is the most common of them and may result from age, genetics, health conditions, or medical treatments. Blocked FALLOPIAN TUBES are also common. Previous ECTOPIC PREGNANCY, abdominal or pelvic surgery, and complications from untreated SEXUALLY TRANSMITTED DISEASES (STDS) may SCAR and otherwise damage the fallopian tubes. Congenital anomalies of the reproductive organs, such as malformations of the UTERUS, may prevent implantation. EATING DISORDERS such as anorexia nervosa and OBESITY influence the body’s endocrine functions and OVULATION. Cigarette smoking, excessive ALCOHOL consumption, and substance abuse also affect FERTILITY.

FEMALE INFERTILITY FACTORS
age over 35excessive ALCOHOL use
anorexia nervosaCHEMOTHERAPY
cigarette smokingCUSHING’S SYNDROME
DIABETESENDOMETRIOSIS
OBESITYOVARIAN CYST
PELVIC INFLAMMATORY DISEASE (PID)PITUITARY GLAND dysfunction
POLYCYSTIC OVARY SYNDROME (PCOS)PREMATURE OVARIAN FAILURE (POF)
previous ECTOPIC PREGNANCYSICKLE CELL DISEASE
RADIATION THERAPYTURNER’S SYNDROME
substance abuseUTERINE FIBROIDS
untreated HYPOTHYROIDISMuterine malformations

Male factor infertility

In male factor infertility the reason for infertility rests with the man. A third of infertility circumstances arise from male factors. Male infertility factors may result from problems with spermatogenesis (production of SPERM), SEMEN production, ERECTION and EJACULATION, sperm count, sperm morphology (structure), and sperm motility (movement). Body temperature and scrotal temperature are crucial for spermatogenesis and sperm survival. Circumstances that prevent the SCROTUM from dropping, such as tight clothing, or sustained exposure to heat, such as sauna or hot tub use, may affect sperm viability. Such effects may be temporary or permanent. Viral infections such as the MUMPS and bacterial EPIDIDYMITIS may damage or destroy testicular tissue. CHROMOSOMAL DISORDERS such as KLINEFELTER’S SYNDROME and endocrine disorders may affect TESTOSTERONE production. Congenital absence of the VAS DEFERENS, which often occurs in men who have CYSTIC FIBROSIS, prevents sperm from leaving the TESTICLES.

MALE INFERTILITY FACTORS
agricultural pesticide exposureATHEROSCLEROSIS
CHEMOTHERAPYchronic ORCHITIS
chronic PROSTATITISchronic URETHRITIS
cigarette smokingCRYPTORCHIDISM
CUSHING’S SYNDROMECYSTIC FIBROSIS
DIABETESDOWN SYNDROME
ERECTILE DYSFUNCTIONexcessive ALCOHOL consumption
HYDROCELEKLINEFELTER’S SYNDROME
HYPOGONADISMlow SPERM count
low SEMEN volumemalformed sperm
low sperm motilityprolonged elevated body temperature
OBESITYRADIATION THERAPY
RETROGRADE EJACULATIONSICKLE CELL DISEASE
SPERMATOCELEsubstance abuse
TESTICULAR CANCERtesticular trauma
untreated EPISPADIASuntreated HYPOSPADIAS
VARICOCELEviral or bacterial EPIDIDYMITIS

Combined factor infertility

In combined factor infertility the reason for infertility results from the unique combination of factors each partner brings to the couple. A third of infertility circumstances arise from combined factors or remain unknown in their origin. Combined factors may be elements that, on their own, would not be sufficient to prevent conception. In particular combinations, however, these elements result in infertility. The woman’s IMMUNE SYSTEM may generate antibodies that attack the man’s sperm. Combined factor infertility is often the most difficult to sort out and treat.

Symptoms of Infertility and Diagnostic Path

The primary symptom of infertility is the absence of pregnancy after one year of unprotected SEXUAL INTERCOURSE when pregnancy is the desired outcome. The diagnostic path begins with comprehensive medical examination, including PELVIC EXAMINATION for women, and detailed history of attempts to conceive. Further diagnostic procedures depend on the preliminary findings and suspicions, though typically include laboratory tests for STDs, BLOOD tests for antibodies and HORMONE levels for the woman, and semen analysis for the man.

Additional diagnostic procedures for the woman may include

  • basal body temperature journaling over several months to assess ovulation
  • pelvic or transvaginal ULTRASOUND to examine the OVARIES and reproductive organs
  • analysis of vaginal fluids to assess acidity (pH) and mucus
  • hysterosalpingogram, a contrast medium X-RAY examination of the uterus and fallopian tubes
  • karyotyping to detect chromosomal abnormalities such as TURNER’S SYNDROME
  • exploratory laparoscopy to visually examine the internal pelvic structures

Additional diagnostic procedures for the man may include

  • blood tests to measure hormone levels
  • scrotal ultrasound to detect HYDROCELEVARICOCELE, or SPERMATOCELE
  • karyotyping to detect chromosomal abnormalities such as Klinefelter’s syndrome

Infertility Treatment Options and Outlook

Treatment targets the identified or suspected cause. Basic approaches include frequent sexual intercourse, sexual positions that support conception, and timing sexual intercourse with ovulation. These basic measures result in conception within two years in about a third of couples. Other straightforward solutions may include treatment for infections or endocrine disorders (such as previously undiagnosed HYPOTHYROIDISM or ADRENAL INSUFFICIENCY).

Further treatment is more invasive. In men, such treatment may consist of surgery to repair hydrocele, varicocele, or spermatocele. Testosterone supplementation often improves sperm production and erectile function in men whose blood testosterone levels are low. In women, further treatment may include surgery to correct or repair various situations that contribute to or cause female factor infertility such as abdominal adhesions, ENDOMETRIOSISUTERINE FIBROIDS, certain uterine malformations, blocked fallopian tubes, and OVARIAN CYST. Hormone supplementation may regulate the MENSTRUAL CYCLE to encourage or stimulate ovulation (“superovulation”) in women. Some hormones used in this way are off-label (not approved for infertility treatment though approved for other uses) in the United States.

Fertility experts select hormone therapies according to the underlying cause for ovulatory dysfunction, the woman’s age, and any existing health conditions. Hormone treatment for infertility may have serious side effects, risks, and complications, including HOT FLASHES, mood swings, ovarian cyst formation, increased risk for spontaneous ABORTION early in pregnancy (miscarriage), and high risk for pregnancy with multiples (twins or greater). The long-term risks associated with fertility drugs, for the women who take them as well as the children conceived with their assistance, remain uncertain because the drugs have not been in use long enough to allow comprehensive studies.

MEDICATIONS USED TO STIMULATE OVULATION
bromocriptine
cabergoline
clomiphene citrate
FOLLICLE-STIMULATING HORMONE (FSH)
GONADOTROPIN-RELEASING HORMONE (GNRH) analogs
human chorionic gonadotropin (hCG)
human menopausal gonadotropin (hMG)
letrozole
metformin

ART methods to combine sperm and OVA may be appropriate when there are no measures to correct the cause of infertility or attempted treatments have not succeeded.

Risk Factors and Preventive Measures

The primary risk factor for infertility is age. Though the time frame of fertility is clearly defined in women, fertility diminishes to some degree in men as they grow older. Lifestyle risk factors include cigarette smoking, alcohol consumption, environmental hazard exposure (such as pesticides), and obesity. Lifestyle also influences some health risks for infertility such as DIABETES, ATHEROSCLEROSIS, and infection with STDs. Risks for which there are no preventive measures include GENETIC DISORDERS and chromosomal disorders, CONGENITAL ANOMALY of the reproductive organs, POLYCYSTIC OVARY SYNDROME (PCOS)PREMATURE OVARIAN FAILURE (POF), endocrine disorders, and AUTOIMMUNE DISORDERS.

See also ADOPTIONAGING, REPRODUCTIVE AND SEXUAL CHANGES THAT OCCUR WITHAMENORRHEA; BIRTH DEFECTS; FETAL ALCOHOL SYNDROME; GENITAL TRAUMA; KARYOTYPE; OFF-LABEL USE; PUBERTY; SMOKING AND HEALTH; SMOKING CESSATION; SURGERY BENEFIT AND RISK ASSESSMENTTUBAL LIGATIONVASECTOMY.

Infertility – male and female – what is, causes, symptoms and treatment
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