Clotting Factors – Definition, Names and List

Definition of Clotting Factors Proteins in the blood that are essential for coagulation. Clotting factors circulate in the blood as inert proteins until the coagulation cascade initiates their conversion into participants in blood clotting. Clotting factors interact with each other as well as other enzymes in the blood, notably fibrin and thrombin, to form blood […]

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Coagulation Cascade – Blood Process

Definition of Coagulation Cascade Coagulation – the process, also called the coagulation cascade, through which the blood forms clots. The cells responsible for forming clots are platelets, which interact with each other, collagen, proteins, and other substances in the blood. Specialized proteins in the blood, called clotting factors, activate in cascades, with one activation leading to another in […]

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Disseminated Intravascular Coagulation (DIC)

Definition of Disseminated Intravascular Coagulation and Treatment Disseminated intravascular coagulation (DIC) – a secondary coagulation disorder arising from an imbalance among the clotting factors in the blood. DIC occurs as a result of a significant underlying health condition such as HIV/AIDS, overwhelming infections, or cancer, and as a serious complication in pregnancy. DIC is a symptom rather than a condition. Indications of its […]

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Hemophilia Disease – Symptoms and Treatment

Definition of Hemophilia A group of inherited genetic disorders in which certain clotting factors are deficient or absent, resulting in clotting dysfunction. People who have hemophilia tend to bleed easily and longer than normal. Some forms of hemophilia carry substantial risk for life-threatening hemorrhage (bleeding). Types of Hemophilia Doctors classify hemophilia according to the deficient clotting factor, which may […]

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Plasma – Definition and Information

Definition of Plasma Plasma – The liquid portion of the blood. Plasma is about 90 percent water and makes up 55 percent of the total blood volume. It contains numerous substances dissolved in it including electrolytes, hormones, enzymes, antibodies, glucose, and clotting factors (specialized proteins). It also carries the blood cells in suspension. Plasma is available for transfusion as […]

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Platelet Aggregation – Definition and Function

Definition of Platelet Aggregation The process through which platelets respond to chemical signals in the blood, allowing them to adhere to each other and to collagen fibers in the blood to form the hemostatic plug that will become a blood clot at the conclusion of the coagulation cascade. The formation of collagen and the conversion […]

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Von Willebrand’s Disease – Symptoms and Treatment

Definition of Von Willebrand’s Disease A hereditary, genetic bleeding disorder resulting from a deficiency or molecular abnormality of clotting factor VIII. Unlike hemophilia A, which also results from clotting factor VIII deficiency, von Willebrand’s disease affects both men and women equally. Its inheritance pattern is autosomal dominant, meaning a child can acquire the condition when […]

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Anticoagulation Therapy

Definition of Anticoagulation Therapy Anticoagulation Therapy is prophylactic (preventive) treatment with medications to reduce the risk of blood clots, broadly including approaches that inhibit various stages of coagulation. Anticoagulation therapy is common treatment for a number of cardiovascular conditions including atrial fibrillation, intermittent claudication, deep vein thrombosis (dvt), pulmonary embolism, and valvular heart disease, and following myocardial infarction (heart attack) and cerebral infarction (ischemic or […]

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