Transforming Growth Factors Definition

Cytokines in the blood circulation that attach to the surfaces of cell membranes. Transforming growth factor alpha (TGF-alpha) stimulates the cells to grow, divide, and differentiate (cell proliferation).

Lymphocytes and macrophages produce TGF-alpha. TGF-beta stimulates interleukin 1 (IL-1) production and blocks the response of lymphocytes in the inflammatory process. Lymphocytes, macrophages, and platelets secrete TGFs.

See also INFLAMMATIONINTERFERONSINTERLEUKINS; LYMPHOCYTEMACROPHAGE; PLATELETTUMOR NECROSIS FACTORS (TNFS).

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