Definition of Tumor Suppressor Gene

Genes that stop cell growth, preventing tumor development. In health, tumor suppressor genes direct the production of proteins to block cell division when there are abnormalities in the cell, such as DNA damage. When mutated, tumor suppressor genes lose the ability to influence cell division.

Cells may then proliferate without regulation, the foundation of cancer. Molecularly targeted therapies and monoclonal antibodies (mabs) show significant promise for altering the function of mutated tumor suppr. genes to restore their ability to block cell growth.

IDENTIFIED TUMOR SUPPRESSOR GENES
GeneCancer Connection
APCcolorectal cancer
BRCA-1/BRCA-2breast cancerovarian cancer
MEN-1/MEN-2multiple endocrine neoplasia (men)
NF1/NF2neurofibromatosis
PTENthyroid cancer
Rbretinoblastoma, osteosarcoma, breast cancer, lung cancer
TP53 (p53)lung cancer, breast cancer, liver cancercervical cancerskin cancerprostate cancer, ovarian cancer
WT1Wilms’s tumor

See also CELL STRUCTURE AND FUNCTION; GENE; ONCOGENES.

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